Puzzle over viral load

Escaping High Viral Load Exhaustion

Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in the face of a high quantity of viral antigen. Although they do not appear to exert immunological pressure in vivo, these CD8 cells are not cla...

Assessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection

  Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.   Materials and...

The relation between symptoms, viral load, and viral load set point in primary HIV infection.

OBJECTIVES To examine the relation between symptoms, initial viral load, and viral load set point in primary HIV infection (PHI). DESIGN Prospective cohort of patients with preseroconversion or recent seroconversion HIV infection (typically <60 days) in San Francisco. METHODS Subjects were questioned about 21 potential PHI symptoms at enrollment and were subsequently followed with viral loa...

HIV viral load messages should go viral in India.

Solving the viral-chemical puzzle of human liver carcinogenesis.

The multifactorial etiology and multistage pathogenesis of HHC3 have fascinated a wide spectrum of cancer researchers for decades. The discovery of HBV and the development of immunological reagents for its detection allowed cancer virologists and epidemiologists to conduct definitive casecontrol studies demonstrating a strikingly high relative risk of HHC in HBV carriers with chronic active hep...